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(172) demonstrated in diabetic rat models that TMAO treatment exacerbated renal inflammation and fibrosis through activation of the NLRP3 inflammasome, promoting IL-1 and IL-18 release and increasing pro-fibrotic TGF-1 expression

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259 Importantly, DHEA may be contraindicated in women with PCOS, who generally have elevated levels of androgens, including DHEA-S

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Additional exclusion criteria included a history of seizures or seizure disorders, or an ASD diagnosis in the presence of normal EEG findings

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