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[3] The wound healing data are more extensive than the cosmetic data and include systemic administration studies

In line with strong and stable interactions of His1-Ala2 of GLP-1 compared with transient interactions of His1-Gly2 in exendin-4, truncation of these two N-terminal residues reduces GLP-1 affinity by 100-300 fold, whereas for exendin-4, this has no effect, albeit for both peptides, these residues are required for GLP-1R-mediated cAMP production 2225

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Medications with Safer Breastfeeding Data: Metformin and Insulin - Options With History Metformin passes into breast milk at low levels and has an established safety record in nursing mothers