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Importantly, there is evidence that the effects of both medications varies by disease stage [47, 48], although results from real-world studies of SGLT2is support their effectiveness on cardiovascular and kidney outcomes in broader populations [49, 50]
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Ce mdicament ne doit pas tre pris pendant la grossesse car on ignore s'il est dangereux pour l'enfant natre
However, certain SGLT2 inhibitors, such as canagliflozin, may be associated with an increased risk of lower limb amputation (LLA), which is more pronounced in patients with preexisting peripheral arterial disease (PAD) and DN, or prior history of amputation [98]
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