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Bottom line While feeling cold is not an official side effect of semaglutide, it can happen to some people as their bodies adjust to a lower caloric intake and weight loss on the medication

Similarly, headaches occurring with signs of hypoglycemia (shakiness, sweating, rapid heartbeat, confusion) require prompt attention, particularly in patients taking insulin or sulfonylureas in addition to semaglutide, as dose adjustments of these medications may be necessary

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Skipped periods A 2023 research review mentioned that losing 10%--15% of your body weight in a short period of time can cause amenorrhea , the medical term for missed periods