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Tirzepatide appears to preserve lean muscle better than many crash diets, but muscle loss can still happen if people: eat too little protein avoid strength training lose weight too aggressively become inactive To support lean muscle preservation during weight loss, many providers recommend: prioritizing protein intake resistance training several times per week staying hydrated avoiding extremely restrictive diets Maintaining muscle mass is important because muscle supports: metabolism strength mobility energy levels long-term weight maintenance How Long Does It Take Tirzepatide to Burn Fat