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The role of copper in this regard is argued to be protective, with copper being released into the synaptic cleft at concentrations of up to 100 M upon depolarization, inhibiting the activity of postsynaptic NMDA, AMPA, and GABA receptors upon binding, thus preventing overstimulation in a negative feedback system (DAmbrosi and Rossi, 2015)
The standard titration schedule from 2.5 mg to 15 mg is the same regardless of whether someone weighs 180 pounds or 350 pounds
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