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The abnormal membrane can also seal the drainage angle, leading to aggressive secondary glaucoma that often needs surgery

These radicals initiate lipid peroxidation of PUFAs within membrane phospholipids, leading to membrane disruption and ferroptosis ( + functions as a cofactor for multiple metabolic enzymesincluding LOXs and PDH1enhancing their activity and further stimulating ROS production ( + influx, elevates ROS levels, and increases cellular sensitivity to ferroptosis

The 33 KDa/55 KDa tau isoforms ratio have also been found to be normal in PD (Borroni et al., 2008, 2009), but decreased in progressive supranuclear palsy (PSP), and normal in patients with diffuse Lewy body disease (DLBD), demented PD patients (PDD), AD, and frontotemporal dementia (FTD) (Borroni et al., 2008, 2009)

TGF- receptors, also known as TGF-R1/TGF-R2, are transmembrane receptors for serine/threonine kinases