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Sulthiame, another carbonic anhydrase inhibitor, significantly reduced OSA severity in patients with moderate-to-severe OSA by over 20 events per hour in a dose-dependent manner, without significantly improved patient-reported outcomes [81]

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The weight loss timeline research from the SURMOUNT clinical trials used 2.5 mg increments every four weeks, but real-world protocols sometimes take smaller steps, especially for researchers who experience significant side effects at standard dose jumps