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Similarly, the other incretin hormone, GIP is efficiently cleaved by DPP-4 in vivo ( It was initially thought that the anti-diabetic effects of DPP-4 inhibition were predominantly due to the enhanced levels of intact GLP-1 [because the insulinotropic effect of GIP is substantially impaired in subjects with T2DM ( Peptide Tyrosine Tyrosine Peptide tyrosine tyrosine (PYY) is another gastrointestinal peptide which is released after food ingestion and which also fulfills the criteria to be classified as a physiological DPP-4 substrate

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Thats where GLP-1 vitamin deficiency and iron B12 fatigue come into play

Healthcare providers need to assist in pointing patients to these resources and informing them as the market evolves