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The upstream regulators of TRAF3IP2 include oxidative stress, RAAS activation and cytokines, including IL-17, whereas the downstream targets are transcriptional factors, such as NF-B and AP-1 and cell signaling pathways such as p38-MAPK and the crosslinking enzyme, lysyl oxidase [189] (Fig

Its also recommended to be cautious in people on certain medications like levodopa (without carbidopa), as mentioned, or those with specific medical conditions, but these are matters of caution rather than strict contraindications