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Due to structural associations, A 2A R activation can inhibit Gi/o protein (G protein subunit, which inhibits adenylyl cyclase activity and thereby decreases cAMP levels) coupled with D 2 R, further validating the existence of the A 2A R-D 2 R heteroreceptor complex [34,35]
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Potential side effects : Although the exact side effects are still unknown, clinical trials have shown that it may cause the same side effects as other medications in this class like nausea, vomiting, diarrhea, constipation and stomach discomfort
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