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Despite this, some practitioners continue to offer it, claiming it helps prevent the muscle loss or intense hunger often associated with 500-calorie diets

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After the initial Phase III studies showed the GLP-1/GIP agonists effectively lowered hemoglobin A1c levels, several influential randomized trials were published investigating their effects on cardiovascular outcomes in diabetic patients

In vitro assays involving fecal slurries supplemented with the fermentation product demonstrated a reduction in TMA levels, and the NGS analysis revealed that Collinsella , Clostridium , and Streptococcus were the most common bacterial genera that produced TMA