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Future trials should prioritize sufficient duration ( 1218 months), include high-risk subgroups (e.g., older adults, frail individuals, patients with rapid or marked weight loss, or chronic comorbidities such as chronic kidney disease), and integrate nutritional and resistance training interventions

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Any genetic alteration leading to loss of function of this tumor suppressor gene product will cause an unopposed catalytic subunit activity, promoting increased cell proliferation in cAMP-responsive cells