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After reviewing data submitted to the FDAs Adverse Event Reporting System between 2018 and 2024, McCall and his coauthors found that compounded GLP-1 medicines were correlated with a greater likelihood of abdominal pain, nausea, diarrhea, gallbladder inflammation, and suicidality compared to standard formulations, as well as more frequent hospitalization for those adverse effects
Instead, by improving metabolic regulation and reducing chronic inflammatory stress, GLP-1 signaling may alter the cellular environment in ways that support more effective management of accumulated molecular damage
SURMOUNT-1 Trial (New England Journal of Medicine, 2022) Randomized, double-blind, placebo-controlled 2,539 participants 72 weeks NCT04184622 Tirzepatide 5 mg -16.0% Mean body weight reduction Tirzepatide 10 mg -21.4% Mean body weight reduction Tirzepatide 15 mg -22.5% Mean body weight reduction Placebo group: -2.4% All results statistically significant (p 27 with Comorbidities Overweight or obese patients (Indian cutoff BMI 23+ with risk factors) seeking significant, sustained weight loss
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