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This accumulation is mediated by plasmalemmal transporters predominantly expressed in glial cell, such as divalent metal transporter 1 DMT1/SLC11A2 or zinc transporter ZIP14/SLC39A14, 374,375 which both transport Fe 2+ (ferrous), whereas Fe 3+ (ferric) is accumulated through transferrin receptors

Russo GT, Giorda CB, Cercone S, De Cosmo S, Nicolucci A, Cucinotta D, et al.Beta cell stress in a 4-year followup of patients with type 2 diabetes: A longitudinal analysis of the BetaDecline Study

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