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Cannabinoid use is independently associated with increases of sympathetic nerve flow.46,47 This influence on sympathetic activity occurs through the inhibition of the activity of the descending gamma-aminobutyric acid (GABA)ergic neurons.4851 Since this descending GABAergic input ultimately inhibits the activity of the rostral ventrolateral medulla (rVLM) neurons,52 the chronic cannabinoid inhibition of this input would be thought to increase the activity of the target rVLM neurons (Fig