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GLP-1 receptor agonists as pharmacologic treatment for obesity after spinal cord injury: clinical considerations

Additionally, in STZ-induced diabetic rats, activity of membrane-bound DPP4 was increased, thereby reducing cardiac SDF-1 concentrations and causing impaired angiogenesis (174)

[1] [3] Understanding these multisystem effects is essential when evaluating potential adverse effects, including fatigue, as the widespread distribution of GLP-1 receptors means these medications influence numerous physiological processes beyond glucose metabolism

Self-medicating or adjusting doses without medical guidance can lead to adverse outcomes