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Because phenylephrine is a potent -1-agonist, it dramatically increases peripheral vascular resistance and afterload (Medical Advisory Board 2026a)

It also causes contraction of the iris sphincter muscle, which constricts the pupil, but maintains some pupillary response to light

Conversely, NRF2 activators like SFN, RSV, and curcumin enhance NRF2-mediated antioxidant defenses, offering cytoprotection in degenerative and inflammatory conditions