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That extra GCGR component is why retatrutide is often discussed as a potential extension of the dual-agonist concept rather than a simple copy of it

Side effects with Wegovy 7.2 mg The STEP UP trial found that side effects were somewhat more common at the 7.2 mg dose than at 2.4 mg: 2 GI side effects: 70.8% (7.2 mg) vs 61.2% (2.4 mg) Dysaesthesia (tingling or numbness): 22.9% (7.2 mg) vs 6.0% (2.4 mg) Discontinuation due to side effects remained low at 3.3% The dysaesthesia finding is notable, though 85.7% of cases resolved while continuing treatment

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