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In PCOS patients, ovarian granulosa cells frequently exhibit elevated oxidative stress markers ( e.g ., malondialdehyde, MDA) alongside reduced activity of antioxidant enzymes ( e.g ., superoxide dismutase, SOD, and glutathione peroxidase 4, GPX4)

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The mean changes in waist circumference relative to baseline were 9.5 cm, 11.0 cm, and 1.5 cm, respectively

Moreover, in recent years the use of small interfering RNAs (siRNA), selectively targeting AGT, as a novel approach of interfering with the RAS has shown beneficial cardio- and nephroprotective properties