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Most private providers follow criteria broadly aligned with NICE guidance: A BMI of 30 or above , or A BMI of 37 or above alongside a weight-related comorbidity such as type 2 diabetes, hypertension, or obstructive sleep apnoea Some providers may consider patients with a BMI slightly below these thresholds at clinical discretion

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For diabetes medications, the FDA requires cardiovascular outcome trials following guidance established in 2008, though this requirement does not universally apply to all weight loss medications

Weiss JF, Srinivasan V, Kumar KS, Landauer MR (1992) Radioprotection by metals: selenium