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There exist a number of crystal and/or cryo-EM structures of them in inactive, intermediate and active states revealing key information about their interactions with various ligands 2,8,14,15 , including dual or triple agonist-bound GLP-1R, GCGR or GIPRG s complexes 16,17,18

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These factors are also linked to the accelerated ageing observed in people with CKD, a key contributor to cognitive decline

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