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These compounds have been also tested in two now completed phase-II and -III trials for the treatment of systemic lupus erythematosus [310] and diabetes mellitus type 1 [311] respectively, showing progressive improvement in disease activity thereby opening the way for new treatment perspectives

KB, particularly -OH-butyrate, also serve as signaling molecules and epigenetic modifier by inhibiting histone deacetylases (HDACs), inducing histone hyperacetylation and promoting specific changes in gene expression [66,67,68,69]

& Todokoro, K

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