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To evaluate their retinal penetration upon delivery via eye drops, solutions of Alexa Fluor 488-conjugated peptides were applied as eye drops to C57BL/6J mice

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When determining the Alanine to Lysine ratio as an indirect measure of mitochondrial distress we found that unaffected children had an average ratio of 5.8 and those with konzo have an average ratio of 6.9, both of which are substantially higher than the expected ratio of less than 3 for healthy adolescents (Fig