Practically, that means IGF-1 LR3 is generally avoided in anyone with a personal or family history that raises cancer concern and it's one more reason this is a medical decision, screened by a provider, not a purchase you make on your own
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Our data suggest that the treatment of colon tumor cells with IGF-1R inhibitors stimulates p70S6K1 activity via MEK1/2 to promote survival, providing a new strategy for colorectal cancer therapeutics
[DOI] [PubMed] [Google Scholar] Shi ZZ, Osei-Frimpong J, Kala G, Kala SV, Barrios RJ, Habib GM, Lukin DJ, Danney CM, Matzuk MM, Lieberman MW