In hepatocytes, hexokinase activity is dependent on the insulin/glucagon ratio for the removal of excess glucose from the blood and its targeting to the glycolytic or glycogenesis pathway, through stimulation of glucose-induced glycogen synthesis 20,21
Furthermore, GLP-1Rs have been shown to be able to stimulate the depolarization-evoked release of other neurotransmitters, such as GABA and glutamate, as well as of serotonin and dopamine, in the cortex and hippocampus (Rebosio et al., 2018)
What the Studies Actually Showed: Preclinical Data Study 1: Fat and Liver Mass Drop Far Faster Than Muscle In diet-induced obese mice treated with tirzepatide (the dual GLP-1/GIP agonist in Mounjaro and Zepbound) for 14 days, researchers found a 73% reduction in body fat and only a 13% reduction in LBM
The process of eating, which releases nutrients, stimulates glucagon-like peptide-1, an appetite hormone we naturally have in our bodies, which decreases appetite and creates fullness