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*Correspondence: Stefan S

When Chapo was at the height of his power, following Mexicos bloody cartel wars of a decade ago, the country enjoyed a period of relative peace what the novelist and drug-war chronicler Don Winslow has dubbed the Pax Sinaloa. But much like how the Islamic State grew from the vacuum of post-Saddam Iraq, one unintended consequence of taking out Chapo may have been opening the door for someone even worse

This suggests that the multi-target regulatory profile of palmatine, evidenced here, may encompass the potential to counteract such complementary cell death modalities, a promising avenue for future investigation

No strong evidence but biological plausibility