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By highlighting both mechanistic insights and translational advances, the review article outlines how next-generation engineered peptide therapeutics, used alone or in combination with existing disease-modifying agents, may help reshape the future landscape of AD diagnosis, prevention, and treatment

The goal is to create a pro-repair, anti-inflammatory environment within the joint, tipping the biological scales from a state of breakdown back toward balance and health

For actin regulation to meaningfully remodel damaged tissue, the signaling environment needs to be maintained across weeks, not days