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As the first supplement of its kind, each tablet delive

J Genet Genomics Yi Chuan Xue Bao

Excess Cu + binds to the lipoyl-lysine residues of DLAT, promoting its oligomerization and functional disruption, which impairs the pyruvate dehydrogenase complex and compromises TCA cycle activity, leading to proteotoxic stress and mitochondrial dysfunction (46)