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These persistence patterns reflect a combination of factors, including side effects, cost barriers, and the chronic nature of obesity treatment, and have important implications for projecting long-term cost offsets and population health outcomes

ZimmermannMBChassardCRohnerFNgoranEKNindjinCDostalAet al

The observed association between frequent in-hospital nondefecation days and subsequent cardiovascular events in patients with ACS in this study aligns with prior research findings indicating that chronic constipation is linked to an adverse cardiovascular prognosis. 6-8 Notably, the cutoff value used in this study (33.8% nondefecation days) corresponds to having at least 1 nondefecation day every 3 days, which is consistent with the commonly accepted clinical definition of constipation (fewer than 3 bowel movements per week)

Typical replacement times vary