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Navigating this transition requires more than a generic eat less approach

In humans, IGF-I also increases renal blood flow and GFR by ~25% and causes volume expansion and sodium retention by a direct action on the renal tubules, with stimulation of rennin release and suppression of atrial natriuretic peptide secretion[364]

KFF, May 2024

Inositol for Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis to Inform the 2023 Update of the International Evidence-based PCOS Guidelines