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10.1097/00008571-199902000-00006 Pharmacogenetics 27 ColombelJ

PLoS Biol 20:e3001714

The KIT gene controls mast cell creation from stem cells in the bone marrow, and mutations in KIT cause excess mast cell proliferation.[ref][ref] A mastocytosis diagnosis is either systemic mastocytosis (affecting the whole body) or cutaneous mastocytosis, which has more skin-related symptoms