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Broad-spectrum antibiotics like ciprofloxacin and metronidazole can almost completely suppress TMAO levels by targeting microbial populations responsible for converting choline, betaine, and L-carnitine into TMA (Wang et al., 2011

And the emergence of GLP-1RA, such as semaglutide, exenatide, and efinopegdutide [116], and so on, can accelerate the drug development of NAFLD which has great therapeutic potential for the treatment of NAFLD [117]

J Biol Chem 283:2912634