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Therefore, folate is crucial for the maintenance of nervous system health

To identify IGF-1-mediated miRNA regulatory networks that cause temozolomide (TMZ) to be insensitive to glioblastoma multiforme treatment, on the basis of comprehensive analysis of multiple databases and in vitro experiments, Chen et al (104) confirmed that IGF-1 upregulated miR-513a-5p signaling reduced the sensitivity of glioma cells to TMZ by inhibiting the NEDD4L-inactivated Wnt/-catenin pathway

Patients with active malignancy, uncontrolled metabolic disease, or a history of endocrine tumors are not appropriate candidates

The three-receptor design creates what researchers describe as a more complete metabolic reset