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However, while short bursts of cAMP may transiently potentiate Ca 2+ release and secretion [72], sustained cAMP elevation could suppress oscillatory Ca 2+ -dependent Cl currents, partly by: redistributing Cl efflux to non-luminal pathways, reducing the amplitude of oscillatory pulses critical for fluid secretion and, possibly dampening Na + -K + -2Cl cotransporter activity [74]

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