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Since tyrosinase-catalyzed reaction is highly associated with local hyperpigmentaiton such as ephelide, melasma and lentigo 5 , discovering of tyrosinase inhibitors are of great importance in cosmetic and medicinal products for the prevention of pigmentation disorders 12

Similarly, enhancing translational confidence will likely require computational augmentation of existing large animal models to incorporate human-specific physiology as well as excipientpeptide interactions under clinically relevant conditions

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Preclinical studies in animals and human case reports have demonstrated that GLP-1 agonists can reduce alcohol consumption, Markku Lhteenvuo, MD, PhD , postdoctoral researcher with the department of forensic psychiatry at the University of Eastern Finland Niuvanniemi Hospital, and colleagues wrote