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Since the discovery and functional verification of GLP-1 in the 1980s ( However, the therapeutic utility of native GLP-1 was limited by its rapid enzymatic degradation and short plasma half-life, which prompted the development of longer-acting receptor agonists

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Wegovy is proven to be effective when taken alongside a diet and exercise plan that involves eating fewer calories and choosing healthier food options

Importantly, the frequency and severity of these reactions often diminish with continued use as patients become more proficient with injection technique and the body adapts to regular subcutaneous administration