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Multiple studies confirm this, including a January 2026 BMJ meta-analysis showing people regain weight four times faster after stopping GLP-1 drugs than after stopping conventional dieting, and a March 2026 Cleveland Clinic real-world study finding 55% of obesity patients gained weight in the year after stopping

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All experiments in rodents were conducted in strict compliance with European Union recommendations (2010/63/EU) and with the guidelines of the European Communities Directive 86/609/EEC regulating animal research