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In clinical trials, people taking Contrave lost an average of about 8% of their initial body weight after 56 weeks, compared to less than 2% in those who took a placebo (inactive medicine)

Does GLP-1 (Glucagon-like peptide-1) receptor agonist therapy affect male fertility and should it be discontinued before attempting pregnancy?

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In human studies, IGFBP2 has been reported to correlate inversely with insulin levels [40], and in the cross-sectional serum proteomics study by Zhi and co-workers, elevated IGFBP2 was observed and validated in individuals with type 1 diabetes [5]