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Remember that NICE guidance on obesity management emphasises the importance of ongoing clinical review for patients taking pharmacological interventions

24(12): p

doi: 10.2337/ds16-0026 47 PauzaAGThakkarPTasicTFelippeIBishopPGreenwoodMPet al

Furthermore, the osteoprotegerin (OPG)/Receptor Activator of Nuclear Factor B Ligand (RANKL) pathway is regulated by GLP-1RAs, increasing the OPG/RANKL ratio to inhibit osteoclast formation and promote bone formation by upregulating osteogenic genes like OC, COL1, Runx2, and ALP [120, 121]