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GLP-1 receptor agonists are medications originally developed for type 2 diabetes management but have since gained popularity for weight loss

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doi: 10.1080/15548627.2016.1256522

In addition to its extensively studied actions in peripheral tissues, studies have evaluated the distribution of GLP-1R in the central nervous system (CNS) of rodents, non-human primates, and humans, showing that it is widely diffused to multiple CNS neurons including neurons of the arcuate nucleus (ARC), which are crucial for the control of energy balance (Fig