[DOI] [PMC free article] [PubMed] [Google Scholar] 7
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Dietary administration of TMAO (0.12% w/w) increases renal tubulointerstitial fibrosis, collagen deposition, and Smad3 phosphorylation in mice and increases aortic lesion area in atherosclerosis-prone ApoE-/- mice
28 Importantly, these studies have also underscored the protective role of antioxidants such as superoxide dismutase, implying that enhancing the body's antioxidant capacity could neutralize the impact of exogenous oxidative stress on hair pigmentation