doi: 10.1038/s41573-025-01231-3
For example, there have been concerns, such as: Thyroid cancer risk, especially with GLP-1 medications like Ozempic Increased chance of heart attacks or blood clots in certain individuals Worsening high blood pressure, especially when paired with other medications Hormonal shifts that could affect mood, sleep, and erectile dysfunction Anyone considering testosterone replacement therapy TRT should share their full medical history with their doctor
Thomas M, Langley B, Berry C, et al
However, oral weight-loss medications do exist: oral Wegovy (semaglutide) was approved in late 2025, and Foundayo (orforglipron), an oral GLP-1 pill from Eli Lilly, was FDA-approved in April 2026