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Mutations were introduced in the genes encoding RAGA (Q66L) and RAGC (S75N) to lock the active state of RAG GTPases (RAGA GTP RAGC GDP )

Extracellular vesicles released during normothermic machine perfusion are associated with human donor kidney characteristics

Sirtuins also perform other post-translational reactions such as NAD + -dependent desuccinylation, diacylation, and demalonylation, and are important in regulating metabolism, allowing metabolic plasticity 7