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Wang YP, Li YH, Guan RX, Liu ZX, Chen XT, Chang RZ, Qiu LJ (2007) The mechanism of root hair development and molecular regulation in plants

By binding to GLP-1 receptors, this peptide suppresses appetite, slows gastric emptying, and enhances insulin secretion

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Whilst gastrointestinal side effects such as diarrhoea and abdominal discomfort are well documented, the question of whether berberine causes constipation specifically is less clear-cut