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Han D, Lerner AG, Vande Walle L, Upton JP, Xu W, Hagen A et al (2009) IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates

The temporal distribution of AE onset demonstrated a median time of 59 days (interquartile range: 16212 days), indicating substantial variability in the latency period of adverse events

Med Sci (Basel) 6(2):33

Similarly, alcohol is fine if consumed in moderation (one drink per day for women, up to two per day for men), but excessive consumption is problematic