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A. V. Arutjunyan, I. G. Popovich, L. S. Kozina, and G. A. Ryzhak, Peptide Regulation of Ageing: From Experiment to Practice, Bentham Science Publishers Ltd., Feb. 2025. doi: 10.2174/0118746098346230250116065407

Leu244 at the 2 nd activity controller position of jr PPO1-wt was mutated to a positively charged arginine (Leu244Arg), leading to a decrease of the k cat values for mono- and diphenolic substrates by 15-fold for tyramine, 4-fold for dopamine and 11-fold for L -DOPA in comparison to jr PPO1-wt (Table 2)

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