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Alternatively, the HPA axis hypofunction might arise from several mechanisms, including chronic inflammation with elevated TNF- levels, a regulatory T cells response with increased IL-10 and transforming growth factor (TGF)-, heightened oxidative and nitrosative stress pathways, notably elevated nitric oxide (NO) production, and infection-related factors like LPS tolerance and viral infections affecting the HPA axis (see Table 2) [79]
Avoid GHK-Cu if you have Wilsons disease (due to the risk of copper accumulation), an active or history of certain cancers (due to growth factor effects and angiogenesis promotion), are pregnant or breastfeeding (safety not definitively established), or have known copper metabolism disorders or peptide allergies
Cells 39 (4), 330336
Biol Chem 384:1118
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