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In addition, cell autonomous primary astrocytopathies can give rise to aberrant astrocytes which drive neuropathological progression, and there is now mounting interest in how astrocytes that are reactive or diseased might have detrimental effects on the outcome of disorders

The method of embodiment 21, wherein the thiophene carboxamide is a compound of Formula (I), Formula (II), Formula (III), Formula (IV), Formula (V), Formula (VI), Formula (VII), Formula (VIII), Formula (IX), Formula (X) or Formula (XI)

;10(7) Wang D, Zhao J, Yang C, Qin D, Zhu D (2025) Aerobic exercise activates let-7e-5p through TP73-AS1 to inhibit the HMGB1/RAGE axis and alleviate asthma airway inflammation and remodeling

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