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Two oligopeptides (Asn-Met-Cys-Ser and Asn-Cys-Pro-Pro) were associated with proteinuria severity, with AUC values of 0.8857 and 0.9963, respectively ( 4.5.3 Methodological considerations in biomarker research 4.5.3.1 Evidence strength assessment and study limitations Current metabolomic investigations predominantly employ cross-sectional designs or case-control methodologies, which harbor intrinsic deficiencies in causal inference